A pioneering early-stage biotechnology company, located in Oxfordshire, is seeking a Principal Scientist to join its growing Biology team. This innovative start-up is developing next-generation oligonucleotide-based therapeutics.
This is a rare opportunity to shape the scientific direction of a company from an early stage, contributing to both discovery and development of a novel class of drug candidates.
**The Role
As Principal Scientist, you will lead the development and implementation of disease-relevant assays for the evaluation of novel oligonucleotide therapeutics. Working closely with the Head of Biology and external collaborators, you will play a critical role in translating early discoveries into preclinical proof-of-concept data.
Key responsibilities:
- Lead development of assays to assess protein up-regulation in disease-relevant cell and animal models.
- Execute and oversee molecular biology experiments (e.g. qPCR, luciferase assays, western blot, ELISA).
- Collaborate with contract research organisations (CROs) and scientific advisors to advance discovery programmes.
- Evaluate new disease indications and help shape strategic direction toward preclinical milestones.
- Maintain rigorous experimental documentation and contribute to internal data presentations and planning.
**About You
Required qualifications and experience:
- PhD in molecular or cell biology, biochemistry, or related field with 7+ years of relevant experience (industry preferred).
- Deep technical expertise in protein quantification (e.g. western blot, ELISA, capillary systems).
- Strong background in mammalian cell culture, nucleic acid transfection, and gene expression analysis.
- Proven experience designing or managing in vivo rodent studies through CROs.
- Excellent communication, organisational and team-working skills.
- Must be able to work on-site at Oxford's Old Road Campus.
Desirable:
- Experience with oligonucleotide-based therapeutic platforms.
- Background in indication finding and disease target assessment.
Ready to make an impact in an early-stage, high-potential biotech?
To apply, please send your CV in word format below or alternatively reach out to Rebecca Tilston @ Smart4Chemicals